Duitama Sandra M, Zurita Javier, Cordoba Diana, Duran Paola, Ilag Leopold, Mejia Wilson
Department of Nutrition and Biochemistry, Faculty of Sciences, Pontifical Xavierian University, Bogota, Colombia.
Department of Environmental Sciences and Analytical Chemistry, Stockholm University, Stockholm, Sweden.
J Paediatr Child Health. 2018 Sep;54(9):997-1004. doi: 10.1111/jpc.13934. Epub 2018 May 20.
To evaluate the intake of a soy protein-based supplement (SPS) and its effects on the sexual maturation and nutritional status of prepubertal children who consumed it for a year.
Healthy children (n = 51) were recruited and randomly assigned to consume the lunch fruit juice with (n = 29) or without (n = 22) addition of 45 g of a commercial soy protein-based supplement (SPS) over 12 months. Nutritional assessment including anthropometry (bodyweight, height, triceps skinfold thickness, mid-upper arm circumference), body mass index (BMI), upper arm muscle area, arm muscle circumference, upper arm area, upper arm fat area data were derived from measures using usual procedures; age and gender-specific percentiles were used as reference. Sexual maturation was measured by Tanner stage. Isoflavones were quantified using liquid chromatography and tandem mass spectrometry.
Height, BMI/age, weight/age and height/age were significantly different (P < 0.05) at 12 months between girls in the control and intervention groups. Statistically significant differences between groups by gender (P < 0.05) were found in boys in the control group for the triceps skinfold thickness and fat area. Nutritional status was adequate according to the World Health Organization parameters. On average, 0.130 mg/kg body weight/day of isoflavones were consumed by children, which did not show significant differences in their sexual maturation.
Consumption of SPS for 12 months did not affect sexual maturation or the onset of puberty in prepubertal boys and girls; however, it may have induced an increase in height, BMI/age, height/age and weight/age of the girls, associated with variations in fat-free mass.
评估一种基于大豆蛋白的补充剂（SPS）的摄入量及其对食用该补充剂一年的青春期前儿童性成熟和营养状况的影响。
招募健康儿童（n = 51），并随机分配他们在12个月内饮用添加（n = 29）或不添加（n = 22）45克市售大豆蛋白补充剂（SPS）的午餐果汁。营养评估包括人体测量学（体重、身高、三头肌皮褶厚度、上臂中部周长）、体重指数（BMI）、上臂肌肉面积、臂肌围、上臂面积、上臂脂肪面积数据，这些数据来自使用常规程序的测量；使用年龄和性别特异性百分位数作为参考。通过坦纳分期法测量性成熟。使用液相色谱和串联质谱法定量异黄酮。
对照组和干预组女孩在12个月时的身高、BMI/年龄、体重/年龄和身高/年龄存在显著差异（P < 0.05）。在对照组男孩中，发现性别组间在三头肌皮褶厚度和脂肪面积方面存在统计学显著差异（P < 0.05）。根据世界卫生组织的参数，营养状况良好。儿童平均每日摄入异黄酮的量为0.130毫克/千克体重，其性成熟未显示出显著差异。
食用SPS 12个月对青春期前男孩和女孩的性成熟或青春期开始没有影响；然而，它可能导致女孩的身高、BMI/年龄、身高/年龄和体重/年龄增加，这与去脂体重的变化有关。
