定义 B 细胞染色质：来自 EBF1 的启示。

Defining B Cell Chromatin: Lessons from EBF1.

机构信息

Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.

出版信息

Trends Genet. 2018 Apr;34(4):257-269. doi: 10.1016/j.tig.2017.12.014. Epub 2018 Jan 11.

DOI:10.1016/j.tig.2017.12.014

PMID:29336845

Abstract

Hematopoiesis is regulated by signals from the microenvironment, transcription factor networks, and changes of the epigenetic landscape. Transcription factors interact with and shape chromatin to allow for lineage- and cell type-specific changes in gene expression. During B lymphopoiesis, epigenetic regulation is observed in multilineage progenitors in which a specific chromatin context is established, at the onset of the B cell differentiation when early B cell factor 1 (EBF1) induces lineage-specific changes in chromatin, during V(D)J recombination and after antigen-driven activation of B cells and terminal differentiation. In this review, we discuss the epigenetic changes underlying B cell differentiation, focusing on the role of transcription factor EBF1 in B cell lineage priming.

摘要

造血是由微环境信号、转录因子网络和表观遗传景观变化调节的。转录因子相互作用并塑造染色质，以允许谱系和细胞类型特异性的基因表达变化。在 B 淋巴细胞发生过程中，多能祖细胞中观察到表观遗传调控，其中在 B 细胞分化开始时，早期 B 细胞因子 1 (EBF1) 诱导染色质的谱系特异性变化时，建立特定的染色质环境，在 V(D)J 重组和抗原驱动的 B 细胞激活以及终末分化后。在这篇综述中，我们讨论了 B 细胞分化的表观遗传变化，重点讨论了转录因子 EBF1 在 B 细胞谱系启动中的作用。