Graduate School of Nanobioscience, Yokohama City University, Seto 22-2, Kanazawa, Yokohama 236-0027, Japan.
Arch Biochem Biophys. 2018 Feb 15;640:47-52. doi: 10.1016/j.abb.2018.01.004. Epub 2018 Jan 11.
Myeloperoxidase (MPO) is a heme-containing peroxidase expressed mainly in neutrophils and to a lesser degree in monocytes. In the presence of hydrogen peroxide and halides, MPO catalyzes the formation of reactive oxygen intermediates, including hypochlorous acid (HOCl). The MPO/HOCl system plays an important role in microbial killing by neutrophils. In addition, MPO has been demonstrated to be a local mediator of tissue damage and the resulting inflammation in various inflammatory diseases. These findings have implicated MPO as an important therapeutic target in the treatment of inflammatory conditions. In contrast to its injurious effects at sites of inflammation, recent studies using animal models of various inflammatory diseases have demonstrated that MPO deficiency results in the exaggeration of inflammatory response, and that it affects neutrophil functions including cytokine production. Given these diverse effects, a growing interest has emerged in the role of this well-studied enzyme in health and disease.
髓过氧化物酶（MPO）是一种主要在中性粒细胞中表达，在程度上也在单核细胞中表达的含血红素过氧化物酶。在过氧化氢和卤化物存在的情况下，MPO 催化活性氧中间体的形成，包括次氯酸（HOCl）。MPO/HOCl 系统在中性粒细胞的微生物杀伤中起重要作用。此外，已经证明 MPO 是各种炎症性疾病中组织损伤和由此产生的炎症的局部介质。这些发现表明 MPO 是治疗炎症性疾病的重要治疗靶点。与在炎症部位的有害作用相反，最近使用各种炎症性疾病的动物模型进行的研究表明，MPO 缺乏会导致炎症反应加剧，并且会影响包括细胞因子产生在内的中性粒细胞功能。鉴于这些不同的影响，人们对这种研究充分的酶在健康和疾病中的作用越来越感兴趣。
