Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China; Key Laboratory for Gastrointestinal Diseases of Gansu Province, Lanzhou University, Lanzhou, China.
Department of Gastroenterology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Cancer Lett. 2018 Apr 1;418:84-96. doi: 10.1016/j.canlet.2018.01.032. Epub 2018 Jan 12.
Decreased expression of miR-551b-3p has been identified in gastric cancer tissues but its biological role and underlying mechanism in this malignancy is poorly understood. In this study, we show that the expression of miR-551b-3p negatively correlates with the depth of tumour invasion and lymphatic metastasis, but it positively correlates with tumour differentiation and the patient survival. MiR-551b-3p negatively affects the proliferation, mobility and invasiveness of gastric cancer cells. LncRNA SMARCC2 inhibits the expression of miR-551b-3p through binding to its mRNA response elements in gastric cancer cells. Overexpression of LncRNA SMARCC2 enhances the proliferation and migration of gastric cancer cells, while inhibition of LncRNA SMARCC2 does the opposite. TMPRSS4 is a direct target gene of miR-551b-3p. We conclude that miR-551b-3p functions as a tumour suppressor gene in gastric cancer, and its function is regulated by LncRNA SMARCC2/miR-551b-3p/TMPRSS4 axis.
miR-551b-3p 的表达在胃癌组织中降低，但它在这种恶性肿瘤中的生物学作用和潜在机制尚不清楚。在本研究中，我们表明 miR-551b-3p 的表达与肿瘤侵袭深度和淋巴转移呈负相关，但与肿瘤分化和患者生存呈正相关。miR-551b-3p 负调控胃癌细胞的增殖、迁移和侵袭。LncRNA SMARCC2 通过与胃癌细胞中其 mRNA 反应元件结合来抑制 miR-551b-3p 的表达。LncRNA SMARCC2 的过表达增强了胃癌细胞的增殖和迁移，而抑制 LncRNA SMARCC2 则起到相反的作用。TMPRSS4 是 miR-551b-3p 的直接靶基因。我们得出结论，miR-551b-3p 在胃癌中作为一种肿瘤抑制基因发挥作用，其功能受 LncRNA SMARCC2/miR-551b-3p/TMPRSS4 轴的调节。
