Szulc-Musioł Beata, Dolińska Barbara, Kołodziejska Justyna, Ryszka Florian
1Department of Applied Pharmacy School of Pharmacy and the Division of Laboratory Medicine Medical University of Silesia, Poland.
2Department of Applied Pharmacy School of Pharmacy and the Division of Laboratory Medicine Medical University of Silesia, Poland.
Acta Pharm. 2017 Dec 20;67(4):569-578. doi: 10.1515/acph-2017-0038.
Effects of two independent variables - the content of quercetin (0 or 1 or 1.5 or 5 %) and the content of plasma (0 or 2 or 4 or 6 %) - on the organoleptic properties and rheological parameters of model formulations prepared on an amphiphilic base were estimated. The consistency of all ointments was uniform, and the content of quercetin and plasma lay within the predefined range. Tested ointments are non-Newtonian systems. The content of quercetin and plasma was found to have a significant effect on the rheological properties of the ointments. An increase in the content of plasma in ointments was accompanied by a significant increase in their hardness, viscosity and shear stress and a reduction of their spreadability. The best rheological properties were shown by formulation F-3, containing 1.5 % of quercetin and 2 % of plasma.
评估了两个自变量——槲皮素含量（0%、1%、1.5%或5%）和血浆含量（0%、2%、4%或6%）——对以两亲性基质制备的模型制剂的感官特性和流变学参数的影响。所有软膏的稠度均一，槲皮素和血浆含量在预定义范围内。测试的软膏为非牛顿体系。发现槲皮素和血浆含量对软膏的流变学性质有显著影响。软膏中血浆含量的增加伴随着其硬度、粘度和剪切应力的显著增加以及铺展性的降低。含有1.5%槲皮素和2%血浆的制剂F-3表现出最佳的流变学性质。
