a Department of Chemistry , Kazmierz Pulaski University of Technology and Humanities , Radom , Poland.
Pharm Dev Technol. 2018 Oct;23(8):780-786. doi: 10.1080/10837450.2017.1322612. Epub 2017 May 8.
The study investigated the effect of chamomile extract obtained in supercritical carbon dioxide conditions on the basic properties of pharmaceutical ointments. A total of five formulations were designed and prepared, differing in the weight ratio of sunflower oil to chamomile extract (5:0, 3.5:1.5, 2.5:2.5, 1.5:3.5 and 0:5). An increase in the concentration of chamomile extract was found to be accompanied by a decrease in hardness, adhesive power and flow limit. Based on viscosity measurements it was shown that ointments containing the hydrophobic plant extract under study were prone to larger drops in viscosity under the effect of the set shear rate. It was determined that from the viewpoint of ointment spreadability and application to the skin, the optimum concentration of chamomile extract for the studied formulations should be within the range of 1.5-2.5%. Furthermore, the addition of chamomile extract to ointments was found to give samples a yellow-green color. Green was observed to be the dominant color, and its saturation and shade varied for different formulations.
该研究调查了在超临界二氧化碳条件下获得的洋甘菊提取物对药用软膏基本性质的影响。共设计并制备了五种配方，它们在葵花籽油与洋甘菊提取物的重量比（5:0、3.5:1.5、2.5:2.5、1.5:3.5 和 0:5）上有所不同。发现随着洋甘菊提取物浓度的增加，硬度、粘附力和流动极限都会降低。通过粘度测量表明，在研究的植物疏水性提取物存在的情况下，含有这种提取物的软膏在设定剪切率的作用下，其粘度更容易大幅下降。从软膏的铺展性和涂敷到皮肤上的角度来看，研究用配方中洋甘菊提取物的最佳浓度应在 1.5-2.5%范围内。此外，向软膏中添加洋甘菊提取物会使样品呈现出黄绿色。观察到绿色是占主导地位的颜色，其饱和度和色调因不同配方而有所不同。
