Epidemiology. 2018 May;29(3):442-447. doi: 10.1097/EDE.0000000000000802.
The nationwide Danish Cancer Registry and the Danish Melanoma Database both record data on melanoma for purposes of monitoring, quality assurance, and research. However, the data quality of the Cancer Registry and the Melanoma Database has not been formally evaluated.
We estimated the positive predictive value (PPV) of melanoma diagnosis for random samples of 200 patients from the Cancer Registry (n = 200) and the Melanoma Database (n = 200) during 2004-2014, using the Danish Pathology Registry as "gold standard" reference. We further validated tumor characteristics in the Cancer Registry and the Melanoma Database. Additionally, we estimated the PPV of in situ melanoma diagnoses in the Melanoma Database, and the sensitivity of melanoma diagnoses in 2004-2014.
The PPVs of melanoma in the Cancer Registry and the Melanoma Database were 97% (95% CI = 94, 99) and 100%. The sensitivity was 90% in the Cancer Registry and 77% in the Melanoma Database. The PPV of in situ melanomas in the Melanoma Database was 97% and the sensitivity was 56%. In the Melanoma Database, we observed PPVs of ulceration of 75% and Breslow thickness of 96%. The PPV of histologic subtypes varied between 87% and 100% in the Cancer Registry and 93% and 100% in the Melanoma Database. The PPVs for anatomical localization were 83%-95% in the Cancer Registry and 93%-100% in the Melanoma Database.
The data quality in both the Cancer Registry and the Melanoma Database is high, supporting their use in epidemiologic studies.
丹麦癌症登记处和丹麦黑素瘤数据库均记录黑素瘤数据，用于监测、质量保证和研究。然而，癌症登记处和黑素瘤数据库的数据质量尚未经过正式评估。
我们使用丹麦病理登记处作为“金标准”参考，估计了 2004 年至 2014 年间癌症登记处（n=200）和黑素瘤数据库（n=200）中随机抽取的 200 名患者的黑色素瘤诊断的阳性预测值（PPV）。我们进一步验证了癌症登记处和黑素瘤数据库中的肿瘤特征。此外，我们还估计了黑素瘤数据库中原位黑色素瘤诊断的 PPV，以及 2004 年至 2014 年间黑色素瘤诊断的灵敏度。
癌症登记处和黑素瘤数据库中黑色素瘤的 PPV 分别为 97%（95%置信区间为 94，99）和 100%。癌症登记处的灵敏度为 90%，黑素瘤数据库的灵敏度为 77%。黑素瘤数据库中原位黑色素瘤的 PPV 为 97%，灵敏度为 56%。黑素瘤数据库中溃疡的 PPV 为 75%，Breslow 厚度的 PPV 为 96%。癌症登记处中组织学亚型的 PPV 为 87%-100%，黑素瘤数据库中的 PPV 为 93%-100%。癌症登记处中解剖学定位的 PPV 为 83%-95%，黑素瘤数据库中的 PPV 为 93%-100%。
癌症登记处和黑素瘤数据库的数据质量都很高，支持它们在流行病学研究中的使用。
