Institute of Microbial Chemistry (BIKAKEN), Tokyo , 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan.
Org Lett. 2018 Feb 2;20(3):612-615. doi: 10.1021/acs.orglett.7b03735. Epub 2018 Jan 17.
Waste-free catalytic assembly of α-amino acids is fueled by a multiboron catalyst that features a characteristic BNO heterocycle, providing a versatile catalytic protocol wherein functionalized natural α-amino acid units are accommodated and commonly used protecting groups are tolerated. The facile dehydrative conditions eliminate the use of engineered peptide coupling reagents, exemplifying a greener catalytic alternative for peptide coupling. The catalysis is sufficiently robust to enable pentapeptide synthesis, constructing all four amide bond linkages in a catalytic fashion.
无废催化合成α-氨基酸由多硼催化剂提供动力，该催化剂具有独特的 BNO 杂环，提供了一种多功能的催化方案，其中可以容纳功能化的天然α-氨基酸单元，并耐受常用的保护基团。温和的脱水条件消除了对工程肽偶联试剂的使用，为肽偶联提供了一种更环保的催化替代方案。该催化体系足够稳健，可以实现五肽的合成，以催化方式构建所有四个酰胺键连接。
