Less Is More: N(BOH) Configuration Exhibits Higher Reactivity than the BNO Heterocycle in Catalytic Dehydrative Amide Formation.

Diboron substructures have emerged as a promising scaffold for the catalytic dehydrative amidation of carboxylic acids and amines. This Letter describes the design, synthesis, and evaluation of the first isolable N(BOH) compound as an amidation catalyst. The new catalyst outperforms the previously reported BNO heterocycle catalyst, with respect to turnover frequency, albeit the former gradually decomposes upon exposure to amines. This work opens up an avenue for designing a better catalyst for direct amidation.