叶提取物对人急性淋巴细胞白血病细胞系的影响。
Effect of leaf extract on human acute lymphoblastic leukaemia cell lines.
作者信息
Santos Janaína M, Cury Nathalia M, Yunes José A, López Jorge A, Hernández-Macedo Maria L
机构信息
a Programa de Pós-Graduação em Biotecnologia Industrial, Universidade Tiradentes/Instituto de Tecnologia e Pesquisa , Aracaju , Brasil.
b Laboratório de Biologia Molecular , Centro Infantil Boldrini , Campinas , Brasil.
出版信息
Nat Prod Res. 2019 Jun;33(11):1633-1636. doi: 10.1080/14786419.2018.1425841. Epub 2018 Jan 16.
leaves are used in folk medicine due its therapeutic properties attributed to phenolic compounds. Therefore, this study was undertaken on its hydroethanolic leaf extract (HE) to evaluate cytotoxicity and apoptosis induction on acute lymphoblastic leukaemia cells. Results indicated that HE interfered in the cell cycle progression, inducing apoptosis by activation of casp3 at lower concentrations, thence, a promising candidate for the development of new cancer drugs.
由于其酚类化合物具有治疗特性，树叶被用于民间医学。因此，本研究对其乙醇叶提取物（HE）进行了研究，以评估其对急性淋巴细胞白血病细胞的细胞毒性和凋亡诱导作用。结果表明，HE干扰细胞周期进程，在较低浓度下通过激活casp3诱导凋亡，因此，它是开发新型抗癌药物的一个有前景的候选物。
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