Konan Nzi André, Bacchi Elfriede Marianne
Departamento de Farmácia, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, CP 66083, Av. Prof. Lineu Prestes 580, B-15 São Paulo, SP 05508-900, Brazil.
J Ethnopharmacol. 2007 Jun 13;112(2):237-42. doi: 10.1016/j.jep.2007.03.003. Epub 2007 Mar 7.
The antiulcerogenic effect of a hydroethanolic extract of Anacardium occidentale L. leaves was investigated. The extract inhibited gastric lesions induced by HCl/ethanol in female rats. A dose-response effect study showed that the ED50 was 150 mg/kgb.w. Extract doses higher than 100 mg/kgb.w. were more effective than 30 mg/kg of lansoprazol in inhibiting gastric lesions. A methanolic fraction (257.12 mg/kg) which reduced gastric lesion at 88.20% is likely to contain the active principle of the antiulcer effect. No signs of acute toxicity were observed when mice were treated with extract dose up to 2000 mg/kgb.w. A chemical analysis of the extract allowed the identification of phenolic compounds as the major components. Glycosylated quercetin, amentoflavone derivate and a tetramer of proanthocyanidin were identified by liquid chromatography coupled to mass spectrometry. The level of total phenolics in the extract was evaluated at 35.5% and flavonoid content was 2.58%.
对腰果树叶乙醇提取物的抗溃疡作用进行了研究。该提取物可抑制雌性大鼠由盐酸/乙醇诱导的胃部损伤。剂量反应效应研究表明，半数有效剂量（ED50）为150毫克/千克体重。高于100毫克/千克体重的提取物剂量在抑制胃部损伤方面比30毫克/千克的兰索拉唑更有效。一种甲醇组分（257.12毫克/千克）使胃部损伤减少了88.20%，可能含有抗溃疡作用的活性成分。当用高达2000毫克/千克体重的提取物剂量处理小鼠时，未观察到急性毒性迹象。对提取物的化学分析鉴定出酚类化合物为主要成分。通过液相色谱-质谱联用鉴定出了糖基化槲皮素、穗花杉双黄酮衍生物和原花青素四聚体。提取物中总酚含量评估为35.5%，黄酮类含量为2.58%。
