Dmitriev A A, Beletskaia L V, Bektimirov R A, Mudrenko I Iu, Bukhova V P
Ter Arkh. 1985;57(6):87-90.
In the majority of diseases with the immune complexes (IC) syndrome, elimination of IC from the body is markedly disturbed. The authors carried out a study with the aid of the direct immunofluorsecence technique. The use of hemosorption in the treatment of patients with grave patterns of systemic lupus erythematosus, rheumatoid arthritis, psoriasis, systemic vasculitis and similar illnesses in conjunction with conventional therapy (corticosteroids, cytostatics) leads to sequestration of the depositions of immune complexes from the skin. As early as after the first hemosorption one can observe the displacement of IC from the derma to the epidermis, advance of IC towards the stratum corneum. After the third session in hemosorption IC granules appear on the body surface, in the form of warty formulations which are removed afterwards together with skin scales. It is assumed that hemosorption recovers the secretory function of the skin, aimed at IC elimination.
在大多数伴有免疫复合物（IC）综合征的疾病中，IC从体内的清除明显受到干扰。作者借助直接免疫荧光技术进行了一项研究。在治疗系统性红斑狼疮、类风湿性关节炎、银屑病、系统性血管炎及类似严重疾病的患者时，将血液吸附与传统疗法（皮质类固醇、细胞抑制剂）联合使用，可使免疫复合物沉积物从皮肤中分离出来。早在第一次血液吸附后，就可以观察到IC从真皮向表皮的转移，IC向角质层推进。在第三次血液吸附疗程后，IC颗粒出现在体表，呈疣状制剂形式，随后与皮屑一起被清除。据推测，血液吸附恢复了皮肤旨在清除IC的分泌功能。
