a State Key Laboratory of Membrane Biology, Institute of Zoology , Chinese Academy of Sciences , Beijing , China.
b Department of Pathology , Beijing University of Chinese Medicine , Beijing , China.
Expert Rev Clin Immunol. 2018 Feb;14(2):115-125. doi: 10.1080/1744666X.2018.1426461. Epub 2018 Jan 23.
B cells mediate allograft rejection through antigen presentation, and production of cytokines and antibodies. More and more immunosuppressive agents specifically targeting B cells and plasma cells have been applied in clinical transplantation. However, recent studies have indicated the regulatory roles of B cells. Therefore, it is vital to clarify the different effects of B cell subsets in organ transplantation so that we can completely understand the diverse functions of B cells in transplantation. Areas covered: This review focuses on the regulatory roles of B cells in transplantation. B cell subsets with immune modulation and factors mediating immunosuppressive functions of regulatory B (Breg) cells were analyzed. Therapies targeting B cells and the application of B cells for transplant tolerance induction were discussed. Expert commentary: Besides involving rejection, B cells could also play regulatory roles in transplantation. Breg cells and the related markers may be used to predict the immune tolerant state in transplant recipients. New therapeutic strategies targeting B cells should be explored to promote tolerance induction with less impact on the host's protective immunity in organ transplanted patients.
B 细胞通过抗原呈递以及细胞因子和抗体的产生来介导移植物排斥反应。越来越多的针对 B 细胞和浆细胞的免疫抑制药物已应用于临床移植。然而，最近的研究表明了 B 细胞的调节作用。因此，阐明 B 细胞亚群在器官移植中的不同作用至关重要，以便我们能够完全理解 B 细胞在移植中的多种功能。
本综述重点关注 B 细胞在移植中的调节作用。分析了具有免疫调节作用的 B 细胞亚群和介导调节性 B（Breg）细胞免疫抑制功能的因子。讨论了针对 B 细胞的治疗方法以及 B 细胞在诱导移植耐受中的应用。
除了参与排斥反应，B 细胞在移植中也可能发挥调节作用。Breg 细胞和相关标记物可用于预测移植受者的免疫耐受状态。应探索针对 B 细胞的新治疗策略，以在器官移植患者中促进诱导耐受，而对宿主的保护性免疫影响较小。
