Department of Odontology, Section of Paediatric Dentistry, Faculty of Medicine, Umeå University, 90185, Umeå, Sweden.
Department of Paediatric Dentistry, Faculty of Odontology, Malmö University, Malmö, Sweden.
Nutr J. 2018 Jan 16;17(1):11. doi: 10.1186/s12937-018-0318-1.
Vitamin D is crucial for mineralized tissue formation and immunological functions. The purpose of this study was to evaluate the association between vitamin D status and dental status in healthy children with vitamin D supplementation in infancy and at 6 years of age.
Eight-year-old children who had participated in a vitamin D intervention project when they were 6 years old were invited to participate in a dental follow-up study. They had fair or darker skin complexion and represented two geographically distant parts of Sweden. 25-hydroxy vitamin D in serum had been measured at 6 years of age and after a 3-month intervention with 25, 10 or 2 (placebo) μg of vitamin D
Dental status was evaluated in 85 of the 206 children in the basic intervention study. Low vitamin D levels were found in 28% at baseline compared to 11% after the intervention, and 34% reported continued intake of vitamin D supplements. Logistic regression supported a weak inverse association between vitamin D status at 6 years of age and caries 2 years later (odds ratio 0.96; p = 0.024) with minor attenuation after an adjustment for potential confounders. Multivariate projection regression confirmed that insufficient vitamin D levels correlated with caries and higher vitamin D levels correlated with being caries-free. Vitamin D status at 6 years of age was unrelated to enamel defects but was positively associated with saliva LL37 levels.
An association between vitamin D status and caries was supported, but it was not completely consistent. Vitamin D status at 6 years of age was unrelated to enamel defects but was positively associated with LL37 expression.
The basic intervention study was registered at ClinicalTrials.gov with register number NCT01741324 www.clinicaltrials.gov/ct2/show/NCT02347293 on November 26, 2012.
维生素 D 对矿化组织形成和免疫功能至关重要。本研究旨在评估在婴儿期和 6 岁时补充维生素 D 的健康儿童中，维生素 D 状况与牙齿状况之间的关联。
邀请参加过 6 岁时维生素 D 干预项目的 8 岁儿童参加牙齿随访研究。他们的皮肤肤色为浅色或深色，代表瑞典的两个地理位置不同的地区。在 6 岁时测量血清 25-羟维生素 D，在 3 个月内每天接受 25、10 或 2（安慰剂）μg 的维生素 D
在基础干预研究的 206 名儿童中，有 85 名儿童对牙齿状况进行了评估。与干预后 11%相比，基线时低维生素 D 水平的比例为 28%，34%的儿童报告继续服用维生素 D 补充剂。Logistic 回归支持 6 岁时维生素 D 水平与 2 年后龋齿之间的弱负相关（比值比 0.96；p=0.024），在调整潜在混杂因素后略有减弱。多元投影回归证实，维生素 D 水平不足与龋齿有关，维生素 D 水平较高与无龋齿有关。6 岁时的维生素 D 水平与牙釉质缺陷无关，但与唾液 LL37 水平呈正相关。
支持维生素 D 状况与龋齿之间存在关联，但不完全一致。6 岁时的维生素 D 水平与牙釉质缺陷无关，但与 LL37 表达呈正相关。
基础干预研究于 2012 年 11 月 26 日在 ClinicalTrials.gov 注册，注册号为 NCT01741324 www.clinicaltrials.gov/ct2/show/NCT02347293。
