在2型糖尿病女性患者中，抑郁症状与血糖控制不佳有关。
Depressive symptoms are associated with poor glycemic control among women with type 2 diabetes mellitus.
作者信息
Góis Carlos, Duarte Tiago Antunes, Paulino Sofia, Raposo João Filipe, do Carmo Isabel, Barbosa António
机构信息
Serviço de Psiquiatria e Saúde Mental do Hospital de Santa Maria-Centro Hospitalar Lisboa Norte, Av. Prof. Egas Moniz, 1649-035, Lisbon, Portugal.
Faculdade de Medicina da Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028, Lisbon, Portugal.
出版信息
BMC Res Notes. 2018 Jan 16;11(1):38. doi: 10.1186/s13104-018-3141-z.
OBJECTIVE
In patients with type 2 diabetes mellitus, depressive symptoms may be associated with metabolic deterioration. The impact of sex on this association is unclear. The aim of this study is to analyze the relationship between depression and metabolic control by sex. The data presented is the side product of the clinical investigation by Rui Duarte, MD, Treatment Response in Type 2 Diabetes Patients with Major Depression from 2007.
RESULTS
A sample of 628 outpatients with type 2 diabetes mellitus was taken from a specialized diabetes outpatient clinic. In a univariate analysis: women's glycohemoglobin mean levels were 8.99% whereas men's were 8.41% and the difference was statistically significant. The proportion of women (34.3%) with pathological levels of depression (Hospital Anxiety Depression Scale score ≥ 8) was significantly higher than men's (15.2%). A linear regression analysis performed by sex and controlling for demographic, clinical and psychological variables, showed poorer metabolic control in women with depressive symptoms. No association was observed in men. These results support depression as a predictor for poor metabolic control in women and the need for detecting depressive symptoms when glycemic levels deteriorate.
目的
在2型糖尿病患者中，抑郁症状可能与代谢恶化有关。性别对这种关联的影响尚不清楚。本研究的目的是按性别分析抑郁症与代谢控制之间的关系。所呈现的数据是2007年医学博士 Rui Duarte 进行的2型糖尿病合并重度抑郁症患者治疗反应临床调查的副产品。
结果
从一家专门的糖尿病门诊选取了628例2型糖尿病门诊患者作为样本。在单因素分析中：女性糖化血红蛋白平均水平为8.99%，而男性为8.41%，差异具有统计学意义。抑郁水平达到病理程度（医院焦虑抑郁量表评分≥8）的女性比例（34.3%）显著高于男性（15.2%）。按性别进行的线性回归分析，并对人口统计学、临床和心理变量进行控制，结果显示有抑郁症状的女性代谢控制较差。在男性中未观察到关联。这些结果支持抑郁症是女性代谢控制不佳的预测因素，以及在血糖水平恶化时检测抑郁症状的必要性。
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