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伴有精神病性症状的重度抑郁发作与 2 型糖尿病:一项 2010-2017 年的纵向研究。

Severe Depressive Episode with Psychotic Symptoms and Type 2 Diabetes: A 2010-2017 Longitudinal Study.

机构信息

Division of Teaching and Outcomes of Education, Faculty of Health Sciences, Medical University of Warsaw, Warsaw, Poland.

Department of Analysis and Strategy, The National Health Fund, Warsaw, Poland.

出版信息

Med Sci Monit. 2019 Mar 8;25:1760-1768. doi: 10.12659/MSM.913356.

DOI:10.12659/MSM.913356
PMID:30846676
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6419531/
Abstract

BACKGROUND There have been few studies published on the prevalence of severe depressive episode in people with type 2 diabetes (T2DM) or its role in adherence to dietary recommendations. We examined the Polish National Health Fund (NFZ) database estimates of all medical visits from 2010 to 2017 to determine the trend and the epidemiology of severe depressive episode in T2DM. MATERIAL AND METHODS The NFZ database was used. We defined the T2DM group diagnosed with both T2DM and severe depressive episode according to the ICD-10 codes. The annual prevalence of severe depressive episode was estimated according to the T2DM diagnosis status, and the age groups were stratified into 8 groups. RESULTS Relative risk for depression (regardless of severity of symptoms) in T2DM is 1.347 [95%CI: 1.342-1.353]. The frequency trend of severe depressive episode with or without psychotic symptoms remains relatively stable. In the case of mild and moderate depressive episode, a downward trend was noted, but they are still the most frequent mood disorders diagnosed. Patients with T2DM aged 20 to 40, for whom the peak of coexistence of these illnesses was noted, are the group particularly vulnerable to depression. Depression also remains on a relatively high but stable level for patients over 60 years of age. CONCLUSIONS The coexistence of depressive episodes in T2DM is a key challenge for medicine and public health. Measures aimed at early identification of patients with T2DM prone to depression need to be taken. Creating multidisciplinary care teams in diabetes management is also necessary.

摘要

背景

关于 2 型糖尿病(T2DM)患者重度抑郁发作的患病率及其对饮食建议依从性的影响,发表的研究较少。我们研究了波兰国家卫生基金(NFZ)数据库中 2010 年至 2017 年所有就诊记录,以确定 T2DM 患者重度抑郁发作的趋势和流行病学情况。

材料和方法

使用 NFZ 数据库。我们根据 ICD-10 代码将同时诊断出 T2DM 和重度抑郁发作的患者定义为 T2DM 组。根据 T2DM 诊断情况估计重度抑郁发作的年度患病率,并按年龄组分为 8 组。

结果

T2DM 患者发生抑郁(无论症状严重程度如何)的相对风险为 1.347[95%CI:1.342-1.353]。伴或不伴精神病性症状的重度抑郁发作的频率趋势保持相对稳定。对于轻度和中度抑郁发作,呈下降趋势,但它们仍然是最常见的诊断出的情绪障碍。患有 T2DM 的 20 至 40 岁患者,其并存这些疾病的高峰年龄,是特别容易抑郁的人群。对于年龄超过 60 岁的患者,抑郁仍然处于相对较高但稳定的水平。

结论

T2DM 中并存的抑郁发作是医学和公共卫生的一个重要挑战。需要采取措施,尽早识别有发生抑郁风险的 T2DM 患者。在糖尿病管理中创建多学科护理团队也是必要的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d362/6419531/728ad4e43417/medscimonit-25-1760-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d362/6419531/571a07dce7ad/medscimonit-25-1760-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d362/6419531/728ad4e43417/medscimonit-25-1760-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d362/6419531/571a07dce7ad/medscimonit-25-1760-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d362/6419531/728ad4e43417/medscimonit-25-1760-g004.jpg

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本文引用的文献

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Depressive symptoms are associated with poor glycemic control among women with type 2 diabetes mellitus.在2型糖尿病女性患者中,抑郁症状与血糖控制不佳有关。
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Primary care patients' expectations regarding medical appointments and their experiences during a visit: does age matter?基层医疗患者对医疗预约的期望及其就诊体验:年龄有影响吗?
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Metabolic Effects of Antidepressant Treatment.抗抑郁治疗的代谢效应
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