Abi-Ayad Meryem, Abbou Amine, Abi-Ayad Fatima Zahra, Behadada Omar, Benyoucef Mohamed
Biology Department, Tlemcen University, Algeria.
Cardiology Department, Tlemcen Hospital Algeria, Algeria.
Diabetes Metab Syndr. 2018 Apr-Jun;12(2):175-179. doi: 10.1016/j.dsx.2017.12.017. Epub 2017 Dec 30.
Hypercholesterolemia and hyper LDL-C are associated with the atherosclerosis (AS). The current study was performed to evaluate the implication of the others lipoproteins (HDL, LDL, VLDL) and apolipoproteins (ApoA1, ApoB100) with subclinical atherosclerosis (carotid plaque) in patients with metabolic syndrome (MetS) free from cardiovascular disease (CVD).
Prospective transversal study was conducted in patients with MetS free from cardiovascular disease (CVD). The lipids, lipoproteins and apolipoproteins were measured. The lipoproteins (HDL, LDL, VLDL) were obtained by the precipitation method. The carotid plaque (CP) was evaluated by ultrasonography, method for assessing AS. Logistic regression and analysis tree were used to look for the association and the incrimination of the lipoproteins with the presence of CP.
The CP incidence was 60% among the participants, 34.29% on the right and the left plaque against 25.71% for only one plaque. The HDL-C was the only lipoprotein associated with the CP after adjustment of the age, the sex and BMI (OR: 0.007 P: 0.046) with the logistic regression analysis, HDL-C (<0.35 g/l), ApoA1 (<1.43 g/l) and VLDL-TG (>0.656 g/l) are implicated in the presence of CP with the analysis tree analysis.
Lower level of HDL-C is associated with CP, HDL-C, ApoA1, and high level VLDL-TG but not total cholesterol, and LDL-Care useful parameters in the assessment of initial atherosclerosis in metabolic syndrome.
高胆固醇血症和高LDL-C与动脉粥样硬化（AS）相关。本研究旨在评估其他脂蛋白（HDL、LDL、VLDL）和载脂蛋白（ApoA1、ApoB100）与无心血管疾病（CVD）的代谢综合征（MetS）患者亚临床动脉粥样硬化（颈动脉斑块）的关系。
对无心血管疾病（CVD）的代谢综合征（MetS）患者进行前瞻性横断面研究。测量血脂、脂蛋白和载脂蛋白。通过沉淀法获得脂蛋白（HDL、LDL、VLDL）。通过超声检查评估颈动脉斑块（CP），这是评估AS的方法。使用逻辑回归和分析树来寻找脂蛋白与CP存在之间的关联及因果关系。
参与者中CP发生率为60%，右侧和左侧斑块发生率为34.29%，仅一处斑块发生率为25.71%。经年龄、性别和BMI调整后，逻辑回归分析显示HDL-C是与CP相关的唯一脂蛋白（OR：0.007，P：0.046），分析树分析表明HDL-C（<0.35g/l）、ApoA1（<1.43g/l）和VLDL-TG（>0.656g/l）与CP的存在有关。
较低水平的HDL-C与CP相关，HDL-C、ApoA1和高水平的VLDL-TG与CP相关，而总胆固醇和LDL-C不是，它们是评估代谢综合征初始动脉粥样硬化的有用参数。
