Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, School of Medicine Tongji University, Shanghai, China.
Shanghai Center of Thyroid Disease, Shanghai, China.
Front Endocrinol (Lausanne). 2021 Feb 22;12:633856. doi: 10.3389/fendo.2021.633856. eCollection 2021.
To investigate the predictive value of baseline serum triglyceride (TG) levels for improvements of metabolism after laparoscopic sleeve gastrectomy (LSG).
112 obese patients [body mass index (BMI) ≥ 35 kg/m] underwent LSG and with complete information of anthropometric and metabolic parameters were divided into normal TG group (group A) and high TG group (group B), while group A had TG levels ≤ 1.7 mmol/L, and group B had TG levels > 1.7 mmol/L. The post-operative changes (Δ) in metabolic parameters between the two groups were compared.
In the whole cohort, the metabolic parameters were significantly improved at 6 months after LSG. BMI and waist circumference (WC) decreased significantly in the two groups. The ΔBMI among group A and group B were 11.42±3.23 vs 9.13±2.77 kg/m (p<0.001), respectively. ΔBMI was positively correlated with ΔWC (r=0.696, p<0.001), Δfasting insulin level (r=0.440, p=0.002), Δfasting serum C peptide level (r=0.453, p=0.002), and Δhomeostasis model assessment insulin resistance index (r=0.418, p=0.004) in group A. Compared with group B, group A had a significantly higher odds ratio (OR) of 2.83 (95% confidence interval [CI]1.25-6.38, p=0.012)and 2.73 (95% CI 1.11-6.72, p=0.029) for ΔBMI and ΔWC after adjustment for age and gender, respectively.
Obese patients with baseline TG levels under 1.7 mmol/L had greater loss of weight at six months follow-up later LSG. This finding suggests that baseline TG level may have a predictive value for weight loss, at least in the short-term follow-up.
探讨基线血清三酰甘油（TG）水平对腹腔镜袖状胃切除术（LSG）后代谢改善的预测价值。
112 名肥胖患者（BMI≥35kg/m²）接受 LSG，并具有完整的人体测量和代谢参数信息，分为正常 TG 组（A 组）和高 TG 组（B 组），其中 A 组 TG 水平≤1.7mmol/L，B 组 TG 水平>1.7mmol/L。比较两组术后代谢参数的变化（Δ）。
在整个队列中，LSG 后 6 个月代谢参数明显改善。两组 BMI 和腰围（WC）均显著下降。A 组和 B 组的ΔBMI 分别为 11.42±3.23kg/m²和 9.13±2.77kg/m²（p<0.001）。ΔBMI 与ΔWC（r=0.696，p<0.001）、Δ空腹胰岛素水平（r=0.440，p=0.002）、Δ空腹血清 C 肽水平（r=0.453，p=0.002）和Δ稳态模型评估胰岛素抵抗指数（r=0.418，p=0.004）呈正相关。与 B 组相比，A 组调整年龄和性别后，ΔBMI 和ΔWC 的比值比（OR）分别为 2.83（95%可信区间 [CI]1.25-6.38，p=0.012）和 2.73（95% CI 1.11-6.72，p=0.029）更高。
基线 TG 水平低于 1.7mmol/L 的肥胖患者在 LSG 后 6 个月随访时体重减轻更多。这一发现表明，基线 TG 水平可能对体重减轻具有预测价值，至少在短期随访中是这样。
