Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technická 3, 166 28 Prague, Czech Republic..
Biotechnol Adv. 2018 May-Jun;36(3):583-602. doi: 10.1016/j.biotechadv.2018.01.007. Epub 2018 Jan 12.
The hallmarks of tumor tissue are not only genetic aberrations but also the presence of metabolic and oxidative stress as a result of hypoxia and lactic acidosis. The stress activates several prosurvival pathways including metabolic remodeling, autophagy, antioxidant response, mitohormesis, and glutaminolysis, whose upregulation in tumors is associated with a poor survival of patients, while their activation in healthy tissue with statins, metformin, physical activity, and natural compounds prevents carcinogenesis. This review emphasizes the dual role of stress response pathways in cancer and suggests the integrative understanding as a basis for the development of rational therapy targeting the stress response.
肿瘤组织的特征不仅在于遗传异常，还在于缺氧和乳酸酸中毒导致的代谢和氧化应激的存在。这种应激会激活几种促进生存的途径，包括代谢重塑、自噬、抗氧化反应、线粒体适应和谷氨酰胺分解，这些途径在肿瘤中的上调与患者预后不良有关，而在他汀类药物、二甲双胍、体育活动和天然化合物等健康组织中激活这些途径可以预防癌症发生。本综述强调了应激反应途径在癌症中的双重作用，并提出了综合理解作为针对应激反应开发合理治疗方法的基础。
