Wink C S, Onge M S, Parker B
Acta Anat (Basel). 1985;124(1-2):117-21. doi: 10.1159/000146105.
In a previous study we reported that castration of adult male rats resulted in femoral osteoporosis 4 months later. The present study tested the effects of dichloromethylene biphosphonate (Cl2MBP, formerly Cl2MDP), a bone resorption inhibitor, on the development of osteoporosis in femora of adult castrated male rats. One-year-old male Holtzman rats were assigned to three groups: sham-operated controls; castrated-no treatment; castrated + Cl2MBP injections 3 times/week. The animals were sacrificed 4 months later. Femora from untreated castrated rats were osteoporotic, confirming our earlier study. Femora from Cl2MBP-treated castrates did not differ from those of controls and were significantly denser and more robust than those of untreated castrated rats. The results indicated that Cl2MBP treatment started immediately after castration prevented the development of femoral osteoporosis in adult castrated male rats.
在之前的一项研究中，我们报告称成年雄性大鼠去势4个月后会导致股骨骨质疏松。本研究测试了骨吸收抑制剂二氯亚甲基二膦酸盐（Cl2MBP，原称Cl2MDP）对成年去势雄性大鼠股骨骨质疏松症发展的影响。将一岁的雄性霍尔茨曼大鼠分为三组：假手术对照组；去势不治疗组；去势 + 每周注射3次Cl2MBP组。4个月后处死动物。未治疗的去势大鼠的股骨出现骨质疏松，这证实了我们早期的研究。接受Cl2MBP治疗的去势大鼠的股骨与对照组无异，且明显比未治疗的去势大鼠的股骨更致密、更坚固。结果表明，去势后立即开始的Cl2MBP治疗可预防成年去势雄性大鼠股骨骨质疏松症的发展。
