Institute of Physical and Applied Chemistry, Faculty of Chemistry, Brno University of Technology, Purkyňova 118, 61200 Brno, Czech Republic; Materials Research Centre, Faculty of Chemistry, Brno University of Technology, Purkyňova 118, 61200 Brno, Czech Republic.
Research Institute and Chemistry Department, SRM Institute of Science and Technology, Chennai, Tamil Nadu, 603203, India.
Int J Biol Macromol. 2018 May;111:680-684. doi: 10.1016/j.ijbiomac.2018.01.068. Epub 2018 Jan 12.
We report a facile methodology for the synthesis of inorganic-organic hydrogels based on integrative assembly of aminopropyl magnesium phyllosilicate (aminoclay) and sodium salt of hyaluronic acid. The viscoelastic materials produced by electrostatic interactions and crosslinking of hyaluronan in the presence of exfoliated synthetic organoclay results in the formation of gel-like behavior retaining a high amount of water. This was confirmed by a rheological study revealing significant dominance of the elastic response over the entire deformation frequency range used. The mechanical strength of the aminoclay-hyaluronan hydrogels was found to be higher than that for related materials based on poly(vinylpyrrolidone)-aminoclay hydrogels.
我们报告了一种基于整合组装氨基丙基镁层状硅酸盐（氨基粘土）和透明质酸钠的无机-有机水凝胶的简便合成方法。在剥离的合成有机粘土存在下，通过透明质酸的静电相互作用和交联产生的粘弹性材料导致凝胶状行为的形成，同时保持高含水量。这通过流变学研究得到了证实，该研究表明在使用的整个变形频率范围内，弹性响应明显占主导地位。发现氨基粘土-透明质酸水凝胶的机械强度高于基于聚（乙烯基吡咯烷酮）-氨基粘土水凝胶的相关材料。
