Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Cancer Epidemiol Biomarkers Prev. 2018 Mar;27(3):315-320. doi: 10.1158/1055-9965.EPI-17-0837. Epub 2018 Jan 16.
Incidence rates of breast carcinomas have increased due to widespread adoption of mammography. Very little is known about why some women with breast cancer later develop second primary breast cancers. In this population-based nested case-control study among breast cancer survivors, including 539 cases with a second primary breast cancer and 994 matched controls, we evaluated the association between first-degree family history of breast cancer and risk of developing a second primary breast cancer. First-degree family history of breast cancer was associated with an increased risk of developing a second primary breast cancer among women with a previous breast cancer [odds ratio (OR) = 1.33, 95% confidence interval (CI), 1.05-1.69] and those with two or more affected first-degree relatives had an even higher risk (OR = 1.94; 95% CI, 1.15-3.28). Those whose relative was diagnosed at less than 50 years old were more likely to develop a second primary breast cancer (OR = 1.78; 95% CI, 1.24-2.57). No difference in risks associated with number or age of affected relatives was observed by menopausal status. Results from this study suggest that first-degree family history of breast cancer may be an important risk factor for development of a second primary breast cancer among women with a previous breast cancer. Given the growing population of breast cancer survivors, a better understanding of risk factors associated with development of a second primary breast cancer is needed to further understand risk. .
由于广泛采用乳房 X 光摄影术，乳腺癌的发病率有所上升。但是，对于为什么一些患有乳腺癌的女性后来会发展出第二个原发性乳腺癌，人们知之甚少。在这项针对乳腺癌幸存者的基于人群的巢式病例对照研究中，包括 539 例第二原发性乳腺癌病例和 994 例匹配对照，我们评估了一级亲属乳腺癌家族史与发展第二原发性乳腺癌风险之间的关系。一级亲属乳腺癌家族史与先前患有乳腺癌的女性发生第二原发性乳腺癌的风险增加相关（比值比 [OR] = 1.33，95%置信区间 [CI]，1.05-1.69），且有两个或更多受影响一级亲属的女性风险更高（OR = 1.94；95% CI，1.15-3.28）。那些相对被诊断为 50 岁以下的人更有可能患上第二原发性乳腺癌（OR = 1.78；95% CI，1.24-2.57）。在绝经状态下，与受影响亲属的数量或年龄相关的风险没有差异。本研究结果表明，一级亲属乳腺癌家族史可能是既往患有乳腺癌的女性发展第二原发性乳腺癌的重要危险因素。鉴于乳腺癌幸存者人数不断增加，需要更好地了解与第二原发性乳腺癌发展相关的风险因素，以进一步了解风险。
