Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.
Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Antimicrob Agents Chemother. 2018 Mar 27;62(4). doi: 10.1128/AAC.02146-17. Print 2018 Apr.
We characterized the synergistic effect produced between pterostilbene and polymyxin B (fractional inhibitory concentration [FIC] index = 0.156 or 0.188) against MCR-producing strains of both human and animal origins. The time-killing assays showed that either pterostilbene or polymyxin B failed to eradicate the - and NDM-positive strain ZJ487, but the combination eliminated the strain by 1 h postinoculation. The survival rate of mice after intraperitoneal infections was significantly enhanced from 0% to 60% in the group in which combination therapy was applied.
我们研究了紫檀芪和黏菌素 B 之间产生的协同作用（抑菌浓度指数 [FIC] 指数 = 0.156 或 0.188）对来自人类和动物来源的 MCR 产生菌株的影响。时间杀伤试验表明，紫檀芪或黏菌素 B 均未能根除 株和 NDM 阳性 株 ZJ487，但组合在接种后 1 小时内消除了该 株。在应用联合治疗的组中，腹腔感染后小鼠的存活率从 0%显著提高到 60%。
