安普霉素对中性粒细胞减少症小鼠大腿模型中多药耐药鲍曼不动杆菌的疗效。
Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model.
机构信息
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
United States Army Medical Department Center and School, Fort Sam Houston, Texas, USA.
出版信息
Antimicrob Agents Chemother. 2018 Mar 27;62(4). doi: 10.1128/AAC.02585-17. Print 2018 Apr.
Abstract
Apramycin, an aminocyclitol aminoglycoside, was rapidly bactericidal against In a neutropenic murine thigh infection model, treatment-associated CFU reductions of >4 log per thigh were observed for all exposures for which area under the curve (AUC)/MIC ratio was >50 and maximum concentration of drug in serum ()/MIC was ≈10 or higher. Based on these findings, we suggest that apramycin deserves further preclinical exploration as a repurposed therapeutic for multidrug-resistant Gram-negative pathogens, including .
摘要
氨丁卡醇，一种氨基环醇氨基糖苷，对 呈快速杀菌作用。在中性粒细胞减少的鼠大腿感染模型中，对于 AUC/MIC 比值大于 50 且血清中药物的最大浓度 ()/MIC 等于或大于 10 的所有暴露，观察到与治疗相关的每大腿 CFU 减少大于 4 对数。基于这些发现，我们认为氨丁卡醇值得进一步进行临床前探索，作为一种重新用于治疗包括 在内的耐多药革兰氏阴性病原体的治疗药物。
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