Han Yong-Seop, Shin Kyung-Sup, Lee Woo-Hyuk, Kim Jung-Yeul
Department of Ophthalmology, Gyeongsang National University College of Medicine, Jinju, Republic of Korea.
Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
Ophthalmologica. 2018;239(2-3):143-150. doi: 10.1159/000481863. Epub 2018 Jan 16.
To investigate the central macular thickness (CMT) and retinal nerve fiber layer (RNFL) thickness in eyes with Vogt-Koyanagi-Harada (VKH) disease associated with optic disc swelling and serous retinal detachment through a 24-month follow-up period.
We prospectively investigated 28 eyes of 14 treatment-naïve patients with acute VKH disease associated with optic disc swelling and serous retinal detachment and 30 eyes of 15 normal individuals to compare changes in the CMT and average RNFL thickness.
The CMT was significantly lower in the eyes of the VKH group at 12 and 24 months. The RNFL thickness was significantly higher in the eyes of the VKH group at the initial visit and at the 6- and 12-month follow-up visits, but no significant difference was found between the VKH group and control group at the 24-month follow-up visit.
Significant changes in the CMT and RNFL thickness in the eyes with VKH disease were observed during the 24-month follow-up period. When diagnosing or monitoring diseases including glaucoma and neuro-ophthalmic diseases that affect the retinal thickness in patients with VKH disease, we recommend considering longitudinal changes in the retinal thickness.
通过24个月的随访期，研究伴有视盘肿胀和浆液性视网膜脱离的Vogt-小柳-原田（VKH）病患者的中心黄斑厚度（CMT）和视网膜神经纤维层（RNFL）厚度。
我们前瞻性地研究了14例初治急性VKH病伴视盘肿胀和浆液性视网膜脱离患者的28只眼，以及15名正常个体的30只眼，以比较CMT和平均RNFL厚度的变化。
VKH组患者在12个月和24个月时的CMT显著降低。VKH组患者在初次就诊时以及6个月和12个月随访时的RNFL厚度显著更高，但在24个月随访时，VKH组与对照组之间未发现显著差异。
在24个月的随访期内，观察到VKH病患者眼睛的CMT和RNFL厚度有显著变化。在诊断或监测包括青光眼和神经眼科疾病在内的、影响VKH病患者视网膜厚度的疾病时，我们建议考虑视网膜厚度的纵向变化。
