血清和唾液乳酸脱氢酶水平作为吸烟者组织损伤生物标志物的生化研究
Serum and salivary lactate dehydrogenase levels as biomarkers of tissue damage among cigarette smokers. A biochemical study.
作者信息
Rao Kumuda, Babu Subhas G, Shetty Urvashi A, Castelino Renita Lorina, Shetty Shishir Ram
机构信息
A. B. Shetty Memorial Institute of Dental Sciences, Nitte University, Deralakatte, Mangalore, Karnataka, India.
出版信息
Stomatologija. 2017;19(3):91-96.
OBJECTIVE
To estimate the serum and salivary lactate dehydrogenase levels in cigarette smokers and non-smokers.
MATERIALS AND METHODS
In this study lactate dehydrogenase levels were estimated in 30 healthy individuals with no tobacco related habits and in 30 patients with history of smoking cigarettes for a minimum of 2 years using Spectrophotometry.
RESULTS
The mean values for serum and salivary lactate dehydrogenase levels were higher in cigarette smokers when compared to non-smokers. Serum lactate dehydrogenase levels on comparison between the groups was statistically significant (p=0.04). The values of salivary lactate dehydrogenase levels between the groups was highly significant (p<0.001).
CONCLUSION
Cigarette smoking leads to an increase in serum as well as salivary Lactate dehydrogenase levels as indicator of tissue damage in the oral cavity. The present study indicates saliva as a better test medium than serum in determination of lactate dehydrogenase levels.
目的
评估吸烟者与非吸烟者血清及唾液中乳酸脱氢酶水平。
材料与方法
本研究采用分光光度法，对30名无烟草相关习惯的健康个体以及30名有至少2年吸烟史的患者的乳酸脱氢酶水平进行评估。
结果
与非吸烟者相比，吸烟者血清及唾液中乳酸脱氢酶的平均值更高。两组间血清乳酸脱氢酶水平比较具有统计学意义（p = 0.04）。两组间唾液乳酸脱氢酶水平差异具有高度统计学意义（p < 0.001）。
结论
吸烟会导致血清及唾液中乳酸脱氢酶水平升高，作为口腔组织损伤的指标。本研究表明，在测定乳酸脱氢酶水平时，唾液是比血清更好的检测介质。
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