Pandarathodiyil Anitha Krishnan, Ramanathan Anand, Garg Ranjana, Doss Jennifer Geraldine, Rahman Fazliny Binti Abd, Ghani Wan Maria Nabillah, Vijayan Srinivas Prasad
Faculty of Dentistry, SEGi University, Jalan Teknologi, Kota Damansara, Petaling Jaya, Selangor, Malaysia.
Department of Oral and Maxillofacial Clinical Sciences, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, Malaysia.
J Pharm Bioallied Sci. 2022 Jul;14(Suppl 1):S1090-S1092. doi: 10.4103/jpbs.jpbs_104_22. Epub 2022 Jul 13.
Lactate dehydrogenase enzyme (LDH) helps in the conversion of glucose into pyruvic acid during aerobic glycolysis and is found in the cytoplasm of most cells in the human body. When oxidative stress occurs in the body, LDH may be released extracellularly and its level is usually indicative of the severity of tissue damage. LDH has proved to be an inestimably resourceful marker in early prediction of serious diseases involving extensive tissue or cellular damage. This short communication explores the potential of LDH as a salivary biomarker of cell injury and death.
乳酸脱氢酶（LDH）在有氧糖酵解过程中有助于将葡萄糖转化为丙酮酸，存在于人体大多数细胞的细胞质中。当体内发生氧化应激时，LDH可能会释放到细胞外，其水平通常表明组织损伤的严重程度。事实证明，LDH在早期预测涉及广泛组织或细胞损伤的严重疾病方面是一种极其有用的标志物。本简短通讯探讨了LDH作为细胞损伤和死亡唾液生物标志物的潜力。
