Zhang Yixin, Cui Xiaoteng, Ning Li, Wei Dianjun
Department of Clinical Laboratory, The Second Hospital of Tianjin Medical University, Tianjin 300211, PR China.
School of Medical Laboratory, Tianjin Medical University, Tianjin 300070, PR China.
Oncotarget. 2017 Nov 30;8(67):111456-111469. doi: 10.18632/oncotarget.22824. eCollection 2017 Dec 19.
This meta-analysis of 23 eligible articles comprehensively and quantitatively evaluated the effects of tumor necrosis factor-α () rs1800629 and rs361525 polymorphisms on sepsis risk. We found that rs1800629 was associated with increased sepsis risk in the overall population in four genetic models, including A vs. G (<0.001, odds ratio (OR)=1.32), GA vs. GG (<0.001, OR=1.46), GA+AA vs. GG (<0.001, OR=1.46), and carrier A vs. carrier G (<0.001, OR=1.32). Subgroup analyses showed a similar result for Asian patients (all <0.05, OR>1). rs361525 was also associated with increased sepsis risk in Asian patients in the four genetic models (all <0.05, OR>1). Begg's and Egger's tests excluded large publication bias, and sensitivity analysis indicated stable results. Our results suggest that the G/A genotype of rs1800629 and rs361525 increases sepsis risk in an Asian population.
这项对23篇符合条件的文章进行的荟萃分析全面且定量地评估了肿瘤坏死因子-α（）rs1800629和rs361525基因多态性对脓毒症风险的影响。我们发现，在包括A与G（<0.001，比值比（OR）=1.32）、GA与GG（<0.001，OR=1.46）、GA+AA与GG（<0.001，OR=1.46）以及携带A与携带G（<0.001，OR=1.32）在内的四种遗传模型中，rs1800629与总体人群中脓毒症风险增加相关。亚组分析显示亚洲患者有类似结果（均<0.05，OR>1）。rs361525在四种遗传模型中也与亚洲患者脓毒症风险增加相关（均<0.05，OR>1）。Begg检验和Egger检验排除了较大的发表偏倚，敏感性分析表明结果稳定。我们的结果提示，rs1800629和rs361525的G/A基因型会增加亚洲人群的脓毒症风险。
