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印度人参根提取物诱导产生的一氧化氮在体外对鸡胚成纤维细胞中的传染性法氏囊病病毒具有抑制作用。

Nitric oxide induced by Indian ginseng root extract inhibits Infectious Bursal Disease virus in chicken embryo fibroblasts in vitro.

作者信息

Ganguly Bhaskar, Umapathi Vijaypillai, Rastogi Sunil Kumar

机构信息

Animal Biotechnology Center, Department of Veterinary Physiology and Biochemistry, College of Veterinary & Animal Sciences, G. B. Pant University of Agriculture & Technology, Pantnagar, 263145 India.

Clinical Research Division, Ayurvet Limited, Katha, 173205 India.

出版信息

J Anim Sci Technol. 2018 Jan 8;60:2. doi: 10.1186/s40781-017-0156-2. eCollection 2018.

DOI:10.1186/s40781-017-0156-2
PMID:29340165
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5759882/
Abstract

Infectious Bursal Disease is a severe viral disease of chicken responsible for serious economic losses to poultry farmers. The causative agent, Infectious Bursal Disease virus, is inhibited by nitric oxide. Root extract of the Indian ginseng, , inhibits Infectious Bursal Disease virus in vitro. Also, root extract is known to induce nitric oxide production in vitro. Therefore, the present study was undertaken to determine if the inhibitory activity of against Infectious Bursal Disease virus was based on the production of nitric oxide. We show that besides other mechanisms, the inhibition of Infectious Bursal Disease virus by involves the production of nitric oxide. Our results also highlight the paradoxical role of nitric oxide in the pathogenesis of Infectious Bursal Disease.

摘要

传染性法氏囊病是鸡的一种严重病毒性疾病，给家禽养殖户造成严重经济损失。病原体传染性法氏囊病病毒可被一氧化氮抑制。印度人参的根提取物在体外可抑制传染性法氏囊病病毒。此外，已知该根提取物在体外可诱导一氧化氮的产生。因此，本研究旨在确定该提取物对传染性法氏囊病病毒的抑制活性是否基于一氧化氮的产生。我们发现，除其他机制外，该提取物对传染性法氏囊病病毒的抑制作用涉及一氧化氮的产生。我们的结果还凸显了一氧化氮在传染性法氏囊病发病机制中的矛盾作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b7a/5759882/55a57705fe94/40781_2017_156_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b7a/5759882/9a939d1761e5/40781_2017_156_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b7a/5759882/1345eb021852/40781_2017_156_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b7a/5759882/2b66a6066bfe/40781_2017_156_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b7a/5759882/55a57705fe94/40781_2017_156_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b7a/5759882/9a939d1761e5/40781_2017_156_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b7a/5759882/1345eb021852/40781_2017_156_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b7a/5759882/2b66a6066bfe/40781_2017_156_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b7a/5759882/55a57705fe94/40781_2017_156_Fig4_HTML.jpg

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