van Dijk Joris D, Jager Pieter L, van Osch Jochen A C, Khodaverdi Maryam, van Dalen Jorn A
Department of Nuclear Medicine, Isala hospital, PO Box 10400, 8000 GK, Zwolle, The Netherlands.
Department of Medical Physics, Isala hospital, Zwolle, The Netherlands.
J Nucl Cardiol. 2019 Aug;26(4):1286-1291. doi: 10.1007/s12350-017-1156-9. Epub 2018 Jan 16.
PET-based myocardial blood flow (MBF) quantification can be inaccurate when using high tracer activities. Our aim was to derive the maximal Rubidium-82 activity for MBF assessment using a new digital PET system and compare the results with conventional analog systems.
1.8 GBq Rubidium-82 was injected into the cardiac insert of an anthropomorphic torso phantom. Data were acquired for 10 min using an Ingenuity TF (Philips Healthcare), Discovery 690 (D690, GE Healthcare), and digital PET prototype system (Philips Healthcare). The dynamic ranges, defined as the maximal measured activity in the reconstructed images deviating < 10% from the true present activity, were determined in all scans.
The dynamic ranges were 312 MBq for Ingenuity TF, 650 MBq for D690, and 654 MBq for digital PET prototype.
The maximal Rb-82 activity for MBF assessment using digital PET prototype is higher than that for its analog counterpart (Ingenuity TF), but seems comparable to the D690.
当使用高示踪剂活性时，基于正电子发射断层扫描（PET）的心肌血流量（MBF）定量可能不准确。我们的目的是使用一种新型数字PET系统得出用于MBF评估的最大铷-82活性，并将结果与传统模拟系统进行比较。
将1.8 GBq铷-82注入一个仿真人体躯干模型的心脏插件中。使用Ingenuity TF（飞利浦医疗保健公司）、Discovery 690（D690，通用电气医疗保健公司）和数字PET原型系统（飞利浦医疗保健公司）采集10分钟的数据。在所有扫描中确定动态范围，动态范围定义为重建图像中测量的最大活性与真实存在活性的偏差<10%。
Ingenuity TF的动态范围为312 MBq，D690为650 MBq，数字PET原型为654 MBq。
使用数字PET原型进行MBF评估的最大铷-82活性高于其模拟对应物（Ingenuity TF），但似乎与D690相当。
