Department of Nuclear Medicine, Isala Hospital, Zwolle, The Netherlands.
Technical Medical Centre, University of Twente, Enschede, The Netherlands.
J Nucl Cardiol. 2022 Feb;29(1):204-212. doi: 10.1007/s12350-020-02141-0. Epub 2020 May 14.
PET scanners using silicon photomultipliers with digital readout (SiPM PET) have an improved temporal and spatial resolution compared to PET scanners using conventional photomultiplier tubes (PMT PET). However, the effect on image quality and visibility of perfusion defects in myocardial perfusion imaging (MPI) is unknown. Our aim was to determine the value of a SiPM PET scanner in MPI.
We prospectively included 30 patients who underwent rest and regadenoson-induced stress Rubidium-82 (Rb-82) MPI on the D690 PMT PET (GE Healthcare) and within three weeks on the Vereos SiPM PET (Philips Healthcare). Two expert readers scored the image quality and assessed the existence of possible defects. In addition, interpreter's confidence, myocardial blood flow (MBF), and myocardial flow reserve (MFR) values were compared.
Image quality improved (P = 0.03) using the Vereos as compared to the D690. Image quality of the Vereos and the D690 was graded fair in 20% and 10%, good in 60% and 50%, and excellent in 20% and 40%, respectively. Defect interpretation and interpreter's confidence did not differ between the D690 and the Vereos (P > 0.50). There were no significant differences in rest MBF (P ≥ 0.29), stress MBF (P ≥ 0.11), and MFR (P ≥ 0.51).
SiPM PET provides an improved image quality in comparison with PMT PET. Defect interpretation, interpreter's confidence, and absolute blood flow measurements were comparable between both systems. SiPM PET is therefore a reliable technique for MPI using Rb-82.
ToetsingOnline NL63853.075.17. Registered 13 November, 2017.
与使用传统光电倍增管（PMT PET）的 PET 扫描仪相比，使用硅光电倍增器和数字读出（SiPM PET）的 PET 扫描仪具有更高的时间和空间分辨率。然而，其对心肌灌注成像（MPI）中灌注缺陷的图像质量和可视性的影响尚不清楚。我们的目的是确定 SiPM PET 扫描仪在 MPI 中的价值。
我们前瞻性地纳入了 30 名患者，他们在 D690 PMT PET（GE Healthcare）上进行了静息和雷加登诺逊诱导应激铷-82（Rb-82）MPI，并在三周内使用 Vereos SiPM PET（Philips Healthcare）进行了检查。两名专家读者对图像质量进行评分，并评估可能存在的缺陷。此外，还比较了解释器的信心、心肌血流（MBF）和心肌血流储备（MFR）值。
与 D690 相比，Vereos 可改善图像质量（P = 0.03）。Vereos 和 D690 的图像质量分别评为差 20%、10%，良 60%、50%，优 20%、40%。D690 和 Vereos 之间的缺陷解释和解释器的信心没有差异（P > 0.50）。静息 MBF（P ≥ 0.29）、应激 MBF（P ≥ 0.11）和 MFR（P ≥ 0.51）均无显著差异。
与 PMT PET 相比，SiPM PET 提供了更高的图像质量。两种系统之间的缺陷解释、解释器的信心和绝对血流测量值具有可比性。因此，SiPM PET 是使用 Rb-82 进行 MPI 的可靠技术。
ToetsingOnline NL63853.075.17。于 2017 年 11 月 13 日注册。
