Guadilla Irene, Calle Daniel, López-Larrubia Pilar
Instituto de Investigaciones Biomédicas "Alberto Sols", CSIC/UAM, Madrid, Spain.
Methods Mol Biol. 2018;1718:89-101. doi: 10.1007/978-1-4939-7531-0_6.
Magnetic resonance imaging (MRI) is a technique based on the contents and relaxation features of water in tissues. In basic MRI sequences, diffusion phenomenon of water molecules is not taken into account although it has a notable influence in the relaxation times, and therefore in the signal intensity of images. In fact, MRI techniques that take advantage of water diffusion have experienced a huge development in last years. Diffusion-weighted imaging (DWI) has spectacularly evolved reaching nowadays a great impact both in clinical and preclinical imaging-especially in the neuroimaging field-and in basic research. We present here a protocol to perform DWI studies in a high-field preclinical setup.
磁共振成像（MRI）是一种基于组织中水分含量和弛豫特性的技术。在基本的MRI序列中，尽管水分子的扩散现象对弛豫时间有显著影响，进而对图像的信号强度有显著影响，但并未考虑该现象。事实上，近年来利用水扩散的MRI技术有了巨大发展。扩散加权成像（DWI）已经取得了显著进展，如今在临床和临床前成像领域，尤其是在神经成像领域以及基础研究中都产生了重大影响。我们在此展示一种在高场临床前设备中进行DWI研究的方案。
