Lope-Piedrafita Silvia
Servei de Ressonància Magnètica Nuclear, Universitat Autònoma de Barcelona, 08193, Cerdanyola del Vallès, Spain.
Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Universitat Autònoma de Barcelona, 08193, Cerdanyola del Vallès, Spain.
Methods Mol Biol. 2018;1718:103-116. doi: 10.1007/978-1-4939-7531-0_7.
Diffusion Tensor Imaging is an MRI technique that allows in vivo noninvasive measurement of the translational motion of water, providing information about its anisotropy (or lack of it) in different tissues. DTI has been commonly used to quantitatively measure the integrity of tissues which may be compromised by neurological disease, such as white matter tracks of the brain, which normally impart significant anisotropy to water motion in healthy brains. However, this anisotropic effect is diminished when axonal or neuronal damage is present. This chapter describes a standard protocol for DTI data acquisition in preclinical studies.
扩散张量成像（Diffusion Tensor Imaging）是一种磁共振成像（MRI）技术，可在体内对水的平移运动进行无创测量，提供不同组织中其各向异性（或缺乏各向异性）的信息。扩散张量成像通常用于定量测量可能因神经疾病而受损的组织的完整性，例如大脑的白质束，在健康大脑中，白质束通常会赋予水运动显著的各向异性。然而，当存在轴突或神经元损伤时，这种各向异性效应会减弱。本章介绍了临床前研究中扩散张量成像数据采集的标准方案。
