Andersson M, Pääbo S, Nilsson T, Peterson P A
Cell. 1985 Nov;43(1):215-22. doi: 10.1016/0092-8674(85)90026-1.
Early region E3 of adenovirus-2 encodes a glycoprotein, E19, that associates with class I MHC antigens. The interaction occurs concomitantly with abrogated terminal glycosylation of class I antigen heavy chains, as shown by pulse-chase and Endo H digestion experiments. Also the viral protein remains in the high mannose form throughout the chase period. These results do not reflect a general impairment of terminal glycosylation of membrane proteins. Immunofluorescence analyses demonstrated that in virally infected cells E19 and class I antigens accumulate in the perinuclear region. Class I antigens gradually disappear from the cell surface. A diminished cell surface expression of class I antigens may be a means by which adenoviruses evade immune surveillance.
腺病毒2型的早期区域E3编码一种糖蛋白E19，它与I类主要组织相容性复合体（MHC）抗原相关。如脉冲追踪和内切糖苷酶H消化实验所示，这种相互作用伴随着I类抗原重链末端糖基化的消除而发生。而且在整个追踪期间，病毒蛋白都保持高甘露糖形式。这些结果并不反映膜蛋白末端糖基化的普遍受损。免疫荧光分析表明，在病毒感染的细胞中，E19和I类抗原在核周区域积累。I类抗原逐渐从细胞表面消失。I类抗原在细胞表面表达的减少可能是腺病毒逃避免疫监视的一种方式。
