Burgert H G, Kvist S
Cell. 1985 Jul;41(3):987-97. doi: 10.1016/s0092-8674(85)80079-9.
The adenovirus type 2 encoded protein E3/19K binds to human histocompatibility class I antigens (HLA). This association occurs both in adenovirus-infected cells and in cells that have been transfected with the gene encoding the E3/19K protein. The formation of the HLA-E3/19K complex prevents the HLA antigens from being correctly processed by inhibiting their terminal glycosylation. This effect is specific for HLA antigens and does not generally involve the glycosyltransferases. Furthermore, the HLA-E3/19K association dramatically reduces the cell surface expression of the HLA antigens. This reduced level of antigens might influence the cytotoxic T cell response. Therefore, our results show a possible molecular mechanism whereby adenoviruses, and perhaps other viruses, delay or escape the cellular immune system of the host.
2型腺病毒编码的E3/19K蛋白与人类组织相容性I类抗原（HLA）结合。这种结合在腺病毒感染的细胞以及转染了编码E3/19K蛋白基因的细胞中均会发生。HLA-E3/19K复合物的形成通过抑制HLA抗原的末端糖基化来阻止其被正确加工。这种效应对HLA抗原具有特异性，一般不涉及糖基转移酶。此外，HLA-E3/19K的结合显著降低了HLA抗原在细胞表面的表达。抗原水平的这种降低可能会影响细胞毒性T细胞反应。因此，我们的结果显示了一种可能的分子机制，腺病毒以及或许其他病毒可借此机制延迟或逃避宿主的细胞免疫系统。
