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肺炎链球菌中lux基因的表达可调节菌毛表达和毒力。

Expression of the lux genes in Streptococcus pneumoniae modulates pilus expression and virulence.

作者信息

Herbert Jenny A, Mitchell Andrea M, Ritchie Ryan, Ma Jiangtao, Ross-Hutchinson Kirsty, Mitchell Timothy J

机构信息

Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.

Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

出版信息

PLoS One. 2018 Jan 17;13(1):e0189426. doi: 10.1371/journal.pone.0189426. eCollection 2018.

DOI:10.1371/journal.pone.0189426
PMID:29342160
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5771582/
Abstract

Bioluminescence has been harnessed for use in bacterial reporter systems and for in vivo imaging of infection in animal models. Strain Xen35, a bioluminescent derivative of Streptococcus pneumoniae serotype 4 strain TIGR4 was previously constructed for use for in vivo imaging of infections in animal models. We have shown that strain Xen35 is less virulent than its parent TIGR4 and that this is associated with the expression of the genes for bioluminescence. The expression of the luxA-E genes in the pneumococcus reduces virulence and down regulates the expression of the pneumococcal pilus.

摘要

生物发光已被用于细菌报告系统以及动物模型中感染的体内成像。肺炎链球菌4型菌株TIGR4的生物发光衍生物Xen35菌株先前已构建用于动物模型中感染的体内成像。我们已经表明，Xen35菌株的毒力低于其亲本TIGR4，并且这与生物发光基因的表达有关。肺炎球菌中luxA-E基因的表达降低了毒力并下调了肺炎球菌菌毛的表达。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6faf/5771582/85738129de89/pone.0189426.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6faf/5771582/33af5c40a56d/pone.0189426.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6faf/5771582/4d7e2bf8c044/pone.0189426.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6faf/5771582/c18b77137ee4/pone.0189426.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6faf/5771582/8177f663dd4a/pone.0189426.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6faf/5771582/c9136f41c917/pone.0189426.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6faf/5771582/4e9b55c17b50/pone.0189426.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6faf/5771582/3b04a77ab644/pone.0189426.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6faf/5771582/322848d55581/pone.0189426.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6faf/5771582/85738129de89/pone.0189426.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6faf/5771582/33af5c40a56d/pone.0189426.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6faf/5771582/4d7e2bf8c044/pone.0189426.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6faf/5771582/c18b77137ee4/pone.0189426.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6faf/5771582/8177f663dd4a/pone.0189426.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6faf/5771582/c9136f41c917/pone.0189426.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6faf/5771582/4e9b55c17b50/pone.0189426.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6faf/5771582/3b04a77ab644/pone.0189426.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6faf/5771582/322848d55581/pone.0189426.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6faf/5771582/85738129de89/pone.0189426.g009.jpg

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