抗肿瘤药物VP 16 - 213的邻醌衍生物或其还原产物对φX174 DNA的灭活作用。

Inactivation of phi X174 DNA by the ortho-quinone derivative or its reduction product of the antitumor agent VP 16-213.

作者信息

van Maanen J M, de Ruiter C, Kootstra P R, Lafleur M V, de Vries J, Retèl J, Pinedo H M

出版信息

Eur J Cancer Clin Oncol. 1985 Oct;21(10):1215-8. doi: 10.1016/0277-5379(85)90018-5.

Abstract

Biologically active phi X174 DNA is inactivated by the ortho-quinone derivative of the antitumor agent VP 16-213, but not by VP 16-213 itself, VP 16-213 phenoxy radical or aqueous decomposition product(s) of the ortho-quinone. Reduction of the ortho-quinone by cytochrome P-450 reductase and NADPH results in deactivation of the ortho-quinone towards anti-phi X174 DNA activity. However, compared with the parent compound VP 16-213, reduction of the ortho-quinone results in substantial damage towards DNA.

摘要

具有生物活性的φX174 DNA可被抗肿瘤药物VP 16 - 213的邻醌衍生物灭活，但不能被VP 16 - 213本身、VP 16 - 213苯氧基自由基或邻醌的水性分解产物灭活。细胞色素P - 450还原酶和NADPH对邻醌的还原作用导致邻醌对φX174 DNA的活性丧失。然而，与母体化合物VP 16 - 213相比，邻醌的还原会对DNA造成严重损伤。