依托泊苷和替尼泊苷。生物分析、代谢及临床药代动力学
Etoposide and teniposide. Bioanalysis, metabolism and clinical pharmacokinetics.
作者信息
Holthuis J J
机构信息
Department of Pharmaceutical Analysis, Faculty of Pharmacy, State University of Utrecht, The Netherlands.
出版信息
Pharm Weekbl Sci. 1988 Jun 17;10(3):101-16. doi: 10.1007/BF01959294.
PMID:3047665
Abstract
Etoposide (VP 16-213) and teniposide (VM 26) are semisynthetic epipodophyllotoxin derivatives active against a variety of tumours. The clinical efficacy has led to an increasing interest in these compounds. This review presents information on the mechanism of action, biochemical pharmacology, bioanalysis, metabolism and pharmacokinetics of etoposide and teniposide.
摘要
依托泊苷（VP 16 - 213）和替尼泊苷（VM 26）是半合成的表鬼臼毒素衍生物，对多种肿瘤具有活性。其临床疗效已引发人们对这些化合物越来越浓厚的兴趣。本综述介绍了依托泊苷和替尼泊苷的作用机制、生化药理学、生物分析、代谢及药代动力学方面的信息。
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