Roytman Michelle, Tassler Andrew B, Kacker Ashutosh, Schwartz Theodore H, Dobri Georgiana A, Strauss Sara B, Capalbo Alyssa M, Magge Rajiv S, Barbaro Marissa, Lin Eaton, Osborne Joseph R
Departments of Radiology.
Otolaryngology, Head and Neck Surgery.
J Neurosurg Case Lessons. 2021 Jan 11;1(2):CASE2058. doi: 10.3171/CASE2058.
Esthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, is a rare sinonasal neuroectodermal malignancy with a slow onset of symptoms, favorable 5-year survival, and a propensity for delayed locoregional recurrence. Current treatment options include resection, adjuvant radiotherapy, and/or chemotherapy; however, because of its rarity and location, determining the optimal treatment for ENB has been challenging.
ENBs strongly express somatostatin receptors (SSTRs), particularly SSTR2, providing a molecular target for imaging and therapy.
The authors present a case series of ENBs imaged with [68Ga]-DOTATATE PET/MRI and PET/CT and discuss the emerging role of [68Ga]-DOTATATE PET for ENB diagnosis, staging, and treatment response monitoring.
嗅神经母细胞瘤（ENB），也称为嗅觉神经母细胞瘤，是一种罕见的鼻窦神经外胚层恶性肿瘤，症状出现缓慢，5年生存率良好，且有局部区域延迟复发的倾向。目前的治疗选择包括手术切除、辅助放疗和/或化疗；然而，由于其罕见性和位置，确定ENB的最佳治疗方法一直具有挑战性。
ENB强烈表达生长抑素受体（SSTRs），尤其是SSTR2，为成像和治疗提供了分子靶点。
作者展示了一组用[68Ga] - DOTATATE PET/MRI和PET/CT成像的ENB病例系列，并讨论了[68Ga] - DOTATATE PET在ENB诊断、分期和治疗反应监测中的新兴作用。
