Holdaway I M, Fraser A, Sheehan A, Croxson M S, France J T, Ibbertson H K
Horm Res. 1985;22(4):253-9. doi: 10.1159/000180103.
A simple photographic technique was used to assess the objective response of hirsute women to treatment with cyproterone acetate (CA). The skin in front of the left ear was shaved and photographs taken immediately and after 1 week, and hair growth per week estimated by averaging the length of 20 hairs in the magnified photographs. The precision, repeatability and patient acceptance of the method were found to be satisfactory. Basal hair growth rates were 2.28 +/- 0.4 mm/week (mean +/- SD, n = 34) and showed a significant correlation with hirsutism scores derived from a standard physician-rated scale. During therapy with CA the mean (+/- SD) improvement in hair growth rate was 19 +/- 13%, whereas physician-rated hirsutism scores improved by 33 +/- 20%. The reduction in hair growth rate showed no significant correlation with improvement assessed using subjective rating by either physician or patient. The greater improvement in physician-rated scores compared with hair growth rate assessment suggests that hair shaft width, colour and other factors may be as important as hair length when assessing treatment response.
采用一种简单的摄影技术来评估多毛女性使用醋酸环丙孕酮（CA）治疗后的客观反应。剃去左耳前方的皮肤毛发，分别在即刻和1周后拍照，并通过放大照片中20根毛发的长度求平均值来估算每周的毛发生长情况。结果发现该方法的精密度、可重复性及患者接受度均令人满意。基础毛发生长率为2.28±0.4毫米/周（均值±标准差，n = 34），且与标准医生评分量表得出的多毛症评分显著相关。在CA治疗期间，毛发生长率的平均（±标准差）改善为19±13%，而医生评定的多毛症评分改善了33±20%。毛发生长率的降低与医生或患者主观评定的改善情况无显著相关性。与毛发生长率评估相比，医生评定分数有更大改善，这表明在评估治疗反应时，毛干宽度、颜色及其他因素可能与毛发长度同样重要。
