Yu Guo, Wu Dan-Na, Yu Yichao, Li Guo-Fu, Zhou Hong-Hao
Subei People's Hospital, Yangzhou University, Yangzhou, China.
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.
J Oncol Pharm Pract. 2019 Mar;25(2):404-408. doi: 10.1177/1078155217752535. Epub 2018 Jan 17.
Many oral anticancer agents are recommended to be given either at least 1 h before or 2 h after a meal, according to the prescribing information. However, the effect of dosage timing of an oral anticancer agent with reference to food intake on anticancer treatment remains unclear. As shown by the literature survey and labeling analysis for oral anticancer drugs approved by the US Food and Drug Administration from 2010 to 2016, labeling information regarding dosage timing for several anticancer drugs appeared not be optimum, leading to suboptimal bioavailability and plasma drug concentrations. This supports a call to regularly recalibrate the labeling information for dosage timing of oral anticancer medications to minimize the risks of compromised efficacy or unintended toxicities.
根据药品说明书，许多口服抗癌药建议在饭前至少1小时或饭后2小时服用。然而，口服抗癌药的给药时间与食物摄入的关系对抗癌治疗的影响仍不明确。文献调查和对2010年至2016年美国食品药品监督管理局批准的口服抗癌药的标签分析表明，几种抗癌药的给药时间标签信息似乎并非最佳，导致生物利用度和血浆药物浓度不理想。这支持了定期重新校准口服抗癌药物给药时间标签信息的呼吁，以尽量减少疗效受损或意外毒性的风险。
