Gasdermin D 为 IL-1 闪现出离港信号。
Gasdermin D Flashes an Exit Signal for IL-1.
机构信息
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
出版信息
Immunity. 2018 Jan 16;48(1):1-3. doi: 10.1016/j.immuni.2018.01.003.
PMID:29343431
Abstract
The IL-1 family of cytokines follows an unconventional pathway of secretion mostly associated with inflammatory cell death. In this issue of Immunity, (Evavold et al., 2017) report gasdermin D pores as channels for active IL-1 release in live phagocytic cells.
摘要
白细胞介素-1（IL-1）家族细胞因子通过非常规分泌途径进行分泌，该途径主要与炎症细胞死亡有关。在本期《免疫》杂志中，（Evavold 等人，2017 年）报道了 Gasdermin D 孔作为活吞噬细胞中活性白细胞介素-1 释放的通道。
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