尼古丁对激光多普勒测量耳蜗血流的影响。

The effects of nicotine on laser Doppler measures of cochlear blood flow.

作者信息

Dengerink H A, Wright J W, Miller J M, Goodwin P

出版信息

Hear Res. 1985;20(1):31-6. doi: 10.1016/0378-5955(85)90056-5.

Abstract

Anesthetized guinea pigs were given arterial bolus injections of saline or varying nicotine concentrations. Blood flow through the cochlea and skin were measured via laser Doppler and arterial blood pressure via an arterial cannula. Cochlear blood flow increased with low doses of nicotine but decreased with the highest dose, while blood pressure increased and skin flow decreased with all doses of nicotine. Control injections of saline vehicle had only minor and transient effects.

摘要

对麻醉后的豚鼠进行动脉推注生理盐水或不同浓度的尼古丁。通过激光多普勒测量耳蜗和皮肤的血流，通过动脉插管测量动脉血压。低剂量尼古丁可使耳蜗血流增加，但高剂量时则减少，而所有剂量的尼古丁均可使血压升高，皮肤血流减少。注射生理盐水对照仅产生轻微和短暂的影响。