Wright J W, Dengerink H A, Miller J M, Goodwin P C
Hear Res. 1985 Jan;17(1):41-6. doi: 10.1016/0378-5955(85)90128-5.
Guinea pigs were exposed to 120 dB white noise for 30 min and evidenced a four-fold elevation in plasma concentration of the potent vasoconstricting hormone angiotensin II (AII). Anesthetized animals received intra-arterial injections of AII at doses that approximated the endogenous levels measured following noise exposure. A marked decrease in skin blood flow was observed with a concomitant increase in cochlear blood flow as measured by laser Doppler flowmeters. Increased cochlear blood flow appeared to be secondary to the increases in systemic blood pressure induced by AII. These findings suggest that cochlear blood flow may increase during periods of intense noise exposure.
将豚鼠暴露于120分贝的白噪声中30分钟，结果显示强效血管收缩激素血管紧张素II（AII）的血浆浓度升高了四倍。对麻醉的动物进行动脉内注射AII，注射剂量接近噪声暴露后测得的内源性水平。用激光多普勒流量计测量发现，皮肤血流量显著减少，同时耳蜗血流量增加。耳蜗血流量增加似乎是由AII引起的全身血压升高所致。这些发现表明，在强烈噪声暴露期间，耳蜗血流量可能会增加。
