Wolff J M, Zitelli J A, Rabin B S, Smiles K A, Abell E
J Am Acad Dermatol. 1985 Oct;13(4):604-12. doi: 10.1016/s0190-9622(85)70205-8.
Twelve patients with early mycosis fungoides were enrolled in a randomized, double-blind, placebo-controlled study. Isolated plaques were injected three times a week with recombinant alpha 2-interferon in nine patients and with the vehicle in three patients. Two additional plaques were evaluated in each patient; one was left untreated, and another was treated topically with either placebo ointment or betamethasone ointment. Biopsies were taken from an untreated, representative plaque prior to treatment and from all test sites following treatment for light microscopy and T lymphocyte subsets. Three of the nine lesions injected with interferon cleared, and all showed improvement. Thirteen of eighteen noninjected lesions improved in patients who received interferon, showing a systemic effect. In the control group, none of the injected lesions improved and only two of the noninjected lesions showed any change. Histopathologic changes confirmed the clinical impression. This study shows that intralesional interferon may be given safely and has a beneficial effect, both locally and systemically.
12例早期蕈样肉芽肿患者参与了一项随机、双盲、安慰剂对照研究。9例患者的孤立斑块每周注射3次重组α2干扰素，3例患者注射赋形剂。每位患者额外评估2个斑块；1个不治疗，另1个局部用安慰剂软膏或倍他米松软膏治疗。治疗前从未经治疗的代表性斑块取材活检，治疗后从所有试验部位取材进行光学显微镜检查和T淋巴细胞亚群分析。注射干扰素的9个皮损中有3个消退，所有皮损均有改善。接受干扰素治疗的患者中，18个未注射的皮损有13个改善，显示出全身效应。在对照组中，注射的皮损均无改善，未注射的皮损只有2个有变化。组织病理学改变证实了临床观察结果。本研究表明，皮损内注射干扰素可安全给药，且局部和全身均有有益作用。
