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E-cadherin and K-ras: implications of a newly developed model of gastric cancer.

作者信息

Till Jacob E, Yoon Sam S, Ryeom Sandra

机构信息

Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

出版信息

Oncoscience. 2017 Nov 28;4(11-12):162-163. doi: 10.18632/oncoscience.379. eCollection 2017 Nov.

DOI:10.18632/oncoscience.379
PMID:29344549
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5769975/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5914/5769975/43d2163a315a/oncoscience-04-0162-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5914/5769975/43d2163a315a/oncoscience-04-0162-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5914/5769975/43d2163a315a/oncoscience-04-0162-g001.jpg

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本文引用的文献

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Mouse models of metastasis: progress and prospects.转移的小鼠模型：进展与展望。
Dis Model Mech. 2017 Sep 1;10(9):1061-1074. doi: 10.1242/dmm.030403.
2
Oncogenic KRAS and p53 Loss Drive Gastric Tumorigenesis in Mice That Can Be Attenuated by E-Cadherin Expression.致癌性KRAS和p53缺失驱动小鼠胃癌发生，而E-钙黏蛋白表达可减弱这种作用。
Cancer Res. 2017 Oct 1;77(19):5349-5359. doi: 10.1158/0008-5472.CAN-17-0061. Epub 2017 Jul 31.
3
Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche.
表达Mist1的胃干细胞维持正常和肿瘤性胃上皮，并由血管周围干细胞生态位提供支持。
Cancer Cell. 2015 Dec 14;28(6):800-814. doi: 10.1016/j.ccell.2015.10.003. Epub 2015 Nov 12.
4
Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer.Apc基因恢复促进细胞分化并重建结直肠癌中的隐窝内环境稳定。
Cell. 2015 Jun 18;161(7):1539-1552. doi: 10.1016/j.cell.2015.05.033.
5
Mechanisms of RAS/β-catenin interactions.RAS/β-catenin 相互作用的机制。
Arch Toxicol. 2013 Apr;87(4):611-32. doi: 10.1007/s00204-013-1035-3. Epub 2013 Mar 13.
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Synergistic tumour suppressor activity of E-cadherin and p53 in a conditional mouse model for metastatic diffuse-type gastric cancer.E-钙黏蛋白和 p53 在条件性转移性弥漫型胃癌小鼠模型中的协同肿瘤抑制活性。
Gut. 2012 Mar;61(3):344-53. doi: 10.1136/gutjnl-2011-300050. Epub 2011 Aug 24.
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