Møller S E, Odum K, Kirk L, Bjerre M, Fog-Møller F, Knudsen A
J Affect Disord. 1985 Nov;9(3):223-9. doi: 10.1016/0165-0327(85)90052-7.
Ratios in plasma of tryptophan (Trp) and tyrosine (Tyr) to other large neutral amino acids were determined in 26 endogenous depressives before and after treatment with nortriptyline in doses adequate to achieve a steady-state serum level between 70 and 130 ng/ml, i.e., within the recommended therapeutic range. Pretreatment plasma Trp ratio and Tyr ratio were normal and did not change significantly during treatment. The plasma Trp and Tyr concentrations and the plasma Trp ratio showed no significant association with the therapeutic response. However, the pretreatment plasma Tyr ratio correlated significantly and directly with the final Hamilton rating score, and inversely with the per cent reduction of Hamilton rating score. Moreover, depressives with plasma Tyr ratio below the normal mean showed significantly greater clinical improvement than patients with higher plasma Tyr ratio with comparable serum nortriptyline levels. Evidence has been presented that biochemical variables in depressed patients are important determinants of clinical improvement following pharmacotherapeutic treatment. Moreover, the results suggest that the plasma Tyr ratio may be a guideline for antidepressant response to nortriptyline.
对26名内源性抑郁症患者在使用去甲替林治疗前后血浆中色氨酸（Trp）和酪氨酸（Tyr）与其他大中性氨基酸的比例进行了测定。去甲替林剂量足以使血清水平达到70至130纳克/毫升的稳态，即在推荐治疗范围内。治疗前血浆色氨酸比例和酪氨酸比例正常，治疗期间无显著变化。血浆色氨酸和酪氨酸浓度以及血浆色氨酸比例与治疗反应无显著关联。然而，治疗前血浆酪氨酸比例与最终汉密尔顿评分显著正相关，与汉密尔顿评分降低百分比呈负相关。此外，血浆酪氨酸比例低于正常均值的抑郁症患者比血浆酪氨酸比例较高且血清去甲替林水平相当的患者临床改善显著更大。有证据表明，抑郁症患者的生化变量是药物治疗后临床改善的重要决定因素。此外，结果表明血浆酪氨酸比例可能是对去甲替林抗抑郁反应的一个指导指标。
