Porter Richard J, Mulder Roger T, Joyce Peter R, Luty Suzanne E
Department of Psychological Medicine, Christchurch School of Medicine & Health Sciences, P.O. Box 4345, Christchurch, New Zealand.
J Affect Disord. 2005 Jun;86(2-3):129-34. doi: 10.1016/j.jad.2004.11.006.
It has been suggested that the ratio of tryptophan (TRP) and tyrosine (TYR) to other large neutral amino acids may predict response to antidepressant drugs with predominantly serotonergic compared with predominantly noradrenergic activity and that this may be clinically useful.
147 subjects with a DSM-III-R diagnosis of major depression underwent a detailed clinical evaluation and prior to treatment had baseline measures of TRP, TYR and other large neutral amino acids (LNAA), prolactin and cortisol. Subjects entered a 6-week randomised treatment trial comparing fluoxetine and nortriptyline.
There was no main effect on 6-week outcome of TRP/LNAA ratio or TYR/LNAA ratio and no interaction between these factors and treatment (fluoxetine vs nortriptyline).
Alterations in antidepressant dose were allowed therefore possibly reducing the effect of TRP or TYR availability on response.
Previous findings that TRP/LNAA and TYR/LNAA ratios may predict differential response to antidepressants were not replicated and neither was our previous finding of a complex relationship between TRP/LNAA and baseline prolactin in predicting 6-week response.
有人提出，色氨酸（TRP）和酪氨酸（TYR）与其他大中性氨基酸的比例，可能预测对抗抑郁药物的反应，与主要具有去甲肾上腺素能活性的药物相比，对主要具有5-羟色胺能活性的药物反应不同，且这可能具有临床实用性。
147名被诊断为DSM-III-R重度抑郁症的受试者接受了详细的临床评估，并在治疗前对TRP、TYR和其他大中性氨基酸（LNAA）、催乳素和皮质醇进行了基线测量。受试者进入一项为期6周的随机治疗试验，比较氟西汀和去甲替林。
TRP/LNAA比值或TYR/LNAA比值对6周治疗结果没有主要影响，且这些因素与治疗（氟西汀与去甲替林）之间没有相互作用。
允许调整抗抑郁药物剂量，因此可能降低了TRP或TYR可用性对反应的影响。
先前关于TRP/LNAA和TYR/LNAA比值可能预测对抗抑郁药物不同反应的研究结果未能重现，我们之前关于TRP/LNAA与基线催乳素之间在预测6周反应方面存在复杂关系的研究结果也未重现。
