Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Department of Chemistry, University of Delhi, Delhi, India.
J Sci Food Agric. 2018 Aug;98(10):3784-3794. doi: 10.1002/jsfa.8892. Epub 2018 Mar 15.
Coumarin derivatives possess a wide range of biological activities. By functionalization of the parent coumarin skeleton that has neither antioxidant nor biological activity, a series of new bio-antioxidants has been designed.
New antioxidant compositions (equimolar binary and ternary mixtures) of eight 4-methylcoumarins and three related compounds have been tested and different effects between individual components have been observed: synergism (positive effect), additivism (summary effect) and antagonism (negative effect). Higher oxidative stability of the lipid substrate was obtained in the presence of the new antioxidant compositions of the studied compounds with dl-α-tocopherol and l-ascorbic acid. The role of each component in the antioxidant compositions of ternary mixtures has been identified by using new equations composed by the authors.
All ternary mixtures demonstrate synergism as a result of continuous regeneration of dl-α-tocopherol from the studied antioxidants and l-ascorbic acid. Theoretical calculations have been probed as indicators of the expected effects between the individual components in a binary mixture. © 2018 Society of Chemical Industry.
香豆素衍生物具有广泛的生物活性。通过对母体香豆素骨架进行功能化，母体香豆素既没有抗氧化活性也没有生物活性，设计了一系列新的生物抗氧化剂。
测试了 8 种 4-甲基香豆素和 3 种相关化合物的等摩尔二元和三元混合物新抗氧化剂组成物，并观察到各组分之间的不同作用：协同作用（正效应）、加和作用（综合效应）和拮抗作用（负效应）。在存在研究化合物的新抗氧化剂组成物与 dl-α-生育酚和 l-抗坏血酸的情况下，脂质基质的氧化稳定性更高。通过作者编写的新方程，确定了三元混合物中每个组分在抗氧化剂混合物中的作用。
所有三元混合物均表现出协同作用，这是由于从研究抗氧化剂和 l-抗坏血酸中不断再生 dl-α-生育酚所致。理论计算已被证明是二元混合物中各组分之间预期作用的指标。© 2018 英国化学学会。
