Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, bl. 9, Sofia 1113, Bulgaria.
Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, bl. 9, Sofia 1113, Bulgaria.
Food Chem. 2014 Aug 15;157:263-74. doi: 10.1016/j.foodchem.2014.02.036. Epub 2014 Feb 19.
Protective effects of recently synthesised dehydrozingerone, M1OH (which is one half of the molecule of curcumin) and dimer of dehydrozingerone, D1(OH)2, as individual compounds (1 mM) and as equimolar binary (1:1) and ternary (1:1:1) mixtures with α-tocopherol (TOH) and/or ascorbyl palmitate (AscPH), were studied during bulk lipid autoxidation at 80 °C. The highest oxidation stability of lipid substrate, in the presence of individual compounds, was found for TOH, followed by D1(OH)2 and M1OH, determined from the main kinetic parameters (antioxidant efficiency, reactivity and capacity). AscPH did not show any protective effect. Synergism was obtained for the binary mixtures of (TOH+AscPH) [42.4%], (M1OH+TOH) [32.4%] and (M1OH+AscPH) [35.6%] and for the ternary mixture of (M1OH+TOH+AscPH) [28.7%]. Different protective effects observed were explained on the basis (of results) of TOH regeneration and its content determined by HPLC. These antioxidant binary and ternary mixtures can be used as functional components of foods with health-promoting effects.
在 80°C 下，对最近合成的脱氢姜酮、M1OH（姜黄素分子的一半）和脱氢姜酮二聚体、D1(OH)2 作为单一化合物（1mM）以及与α-生育酚 (TOH) 和/或抗坏血酸棕榈酸酯 (AscPH) 等摩尔二元（1:1）和三元（1:1:1）混合物在大量脂质自动氧化过程中的保护作用进行了研究。在存在单一化合物的情况下，脂质底物的最高氧化稳定性是 TOH，其次是 D1(OH)2 和 M1OH，这是从主要动力学参数（抗氧化效率、反应性和容量）确定的。AscPH 没有显示出任何保护作用。（TOH+AscPH）[42.4%]、（M1OH+TOH）[32.4%]和（M1OH+AscPH）[35.6%]二元混合物以及（M1OH+TOH+AscPH）[28.7%]三元混合物表现出协同作用。根据 HPLC 测定的 TOH 再生及其含量，解释了观察到的不同保护作用。这些具有抗氧化作用的二元和三元混合物可用作具有促进健康作用的功能性食品成分。
